肿瘤学模型和科技聚焦

阅读科学家的观点聚焦,查看对临床前肿瘤模型和技术的深度解析。

A20:小鼠B细胞淋巴瘤建模

Researchers are using preclinical mouse modeling in an effort to employ conventional treatment methods for lymphoma, such as radiotherapy and chemotherapy, in combination with immunomodulatory agents to more effectively treat this disease. Covance has developed the syngeneic A20 tumor model, a B cell lymphoma, to support these immuno-oncology applications.
了解详情

A549 - 非小细胞肺癌模型

Today a large number of human non-small cell lung cancer cell lines exist that are being used for both basic research and drug discovery. One commonly used line is A549, an epithelial carcinoma derived from a 58 year old male patient, known to be KRAS mutant and EGFR wild type.

了解详情

CT26:鼠结肠癌

在临床前,鼠类CT26结肠癌系已成为评估具有免疫检查点抑制剂抗体的药物组合潜力的平台模型。它是一种高免疫原性肿瘤,倾向于表现出对许多市售检查点抑制剂的客观应答率。科文斯在过去的9个月内运行了十多次该模型,并定期安排其他研究。

了解详情

E0771同基因乳腺癌模型

In this spotlight, we present data from our initial growth and efficacy studies with the E0771 model. The data presented here provides an overview of the E0771 cell line's response to immuno-oncology agents and radiation therapy to enable design of rational combination studies.

了解详情

ID8:用于测试卵巢癌免疫疗法的同系小鼠模型

ID8-Luc is a novel syngeneic mouse model developed to treat orthotopic ovarian cancer. Ovarian cancer remains a significant unmet medical need with a relative 5-year survival rate of 17% in patients diagnosed with highly advanced stage IV ovarian cancer.

了解详情


深入研究浸润肿瘤的T细胞免疫表型

In this Tech Spotlight, we demonstrate the latter capability by presenting data generated using the new Expanded CompT™ panel, a 16-color panel that takes flow analysis of T cell activation and differentiation to a level above any other panel in the Covance service portfolio.
了解详情

流式细胞仪绝对计数 - 最大限度地提高免疫表型数据解释的准确性

In this Tech Spotlight we will present the principles of absolute counting and the advantages this service provides when used in combination with tumor immunophenotypic analysis.
了解详情

使用新型CompDC™测试套组通过流式细胞术进行全面的树突状细胞分析

To address the growing need for robust comprehensive DC immunophenotyping in murine pre-clinical models, Covance has configured a new standard panel, CompDC™. In this Tech Spotlight, we will demonstrate how various DC subsets in tumor and other tissue-derived cell samples can be analyzed using this panel.
了解详情

蛋白质表达模式、共同表达与空间关系的多重免疫组化

多重免疫组织化学(IHC)是一种利用单一抗原染色的基本概念同时检测多个标记物的检测方法。它可实现对过氧化物酶、碱性磷酸酶和其他偶联的一抗或二抗的标记,并可使用多种常见方法来实现,包括间接或直接染色方案。
了解详情

使用磷酸流式细胞仪检测实体瘤中的磷酸蛋白

In this article, we will be presenting phospho-protein detection in solid tumors using phospho-flow cytometry and reviewing the analysis of cabozantinib-induced inhibition of PI3K/AKT and JAK-STAT signaling in tumor vs. host immune cells.
了解详情

全部观点聚焦 >